Annual Report 2017

I.Achievement of Research Activities in 2017


I. Nishimura, Y. Shiwa, A. Sato, T. Oguma, H. Yoshikawa, Y. Koyama
Comparative genomics of Tetragenococcus halophilus.
J. Gen. Appl. Microbiol., 63, 369–372 (2017)

F.-J. Jin, P. Han, M. Zhuang, Z.-M. Zhang, L. Jin, Y. Koyama
Comparative proteomic analysis: SclR is importantly involved in carbohydrate metabolism in Aspergillus oryzae.
Appl. Microbiol. Biotechnol., 102: 319–332 (2017)

I. Nishimura, Y. Shinohara, T. Oguma, Y. Koyama
Survival strategy of the salt-tolerant lactic acid bacterium, Tetragenococcus halophilus, to counteract koji mold, Aspergillus oryzae, in soy sauce brewing.
Biosci, Biotechnol, Biochem., in press

II.Grant project

NISR has started a new project, which supports a research fund in the field of applied biology for the purpose of developing the fermentation and brewing industry.

1) 2017 NISR Research Grant

Yoichi HONDA (Kyoto University)
Mechanism for mRNA maturation control in basidiomycetes

Shingo IZAWA (Kyoto Institute of Technology)
Study on the preferential translation under the pronounced translation repression caused by brewing-related stress in Saccharomyces cerevisiae

Hiroshi KADOKURA (Tohoku University)
Identification of PDI family members required for the production of useful proteins

Takuji OKA (Sojo University)
Fundamental research on the biosynthesis of fungal-type galactomannan (FTGM) as a new drug target

Masahiro OKADA (The University of Tokyo)
Screening of secondary metabolites by genome shuffling

Sachiko TSUKAMOTO (Kumamoto University)
Activation of production of new biologically active compounds by combined culture of fungi and study on the mechanism

2) 2017 NISR Young Investigator Research Grant

Naoya KATAOKA (Yamaguchi University)
Metabolic engineering of coryneform bacteria for enhanced supply of acetyl-CoA and its application to fermentative production of useful compounds

Akimasa MIYANAGA (Tokyo Institute of Technology)
Functional analysis of post-PKS enzymes in hitachimycin biosynthesis

Kei NANATANI (Tohoku University)
Structural and functional analyses of bacterial organic acid exporters for efficient organic acid production by fermentation

Kenji OKANO (Osaka University)
Construction of a platform strain for anaerobic bioprocessing and its application to biofuel production

Motoyuki SHIMIZU (Meijo University)
Proteomics-based screening and functional characterization of the novel enzymes involved in degradation of wood components from filamentous fungi

Yota TSUGE (Kanazawa University)
Two-stage production of polyamide monomers using oxygen as a metabolic switch

3) 2016 NISR Research Grant

Masaki MIZUNUMA (Hiroshima University)
Analysis of a novel stress tolerance mechanism in yeast

Hideaki NOJIRI (The University of Tokyo)
Structural bases of electron transfer and reaction cycle of ring- hydroxylating dioxygenase systems

Hikaru SEKI (Osaka University)
Production of guaianolide sesquiterpene lactones in engineered yeast

Kyoko TAKAHASHI (Nihon University)
Regulation of allergic reactions of mast cells by intestinal bacteria and probiotics

Daisuke UMENO (Chiba University)
Evolutionary design of gene expression systems

4) 2016 NISR Young Investigator Research Grant

Takayoshi AWAKAWA (The University of Tokyo)
Construction of a novel meroterpenoid biosynthetic pathway in Aspergillus oryzae

Makoto HASHIMOTO (Iwate Medical University)
Construction of biosynthetic machinery for polyketides with a bis-tetrahydrofuran moiety

Yujiro HIGUCHI (Kyushu University)
Functional analysis of SM proteins for heterologous protein production in Aspergillus oryzae

Takehito NAKAZAWA (Kyoto University)
Effects of secondary metabolism on sexual development and wood decay in agaricomycetes

Ryo NASUNO (Nara Institute of Science and Technology)
A novel arginine metabolic pathway regulated by the yeast N-acetyltransferase Mpr1

Yuko SHIMAMURA (University of Shizuoka)
Elucidation of the gene transfer mechanism of staphylococcal enterotoxin A

5) 2015 NISR Research Grant

Tomoyuki NAKAGAWA (Gifu University)
Molecular mechanism for the aldehyde tolerance of S.cerevisiae and its application in the fermentation industry

6) 2015 NISR Young Investigator Research Grant

Yudai MATSUDA (The University of Tokyo)
Creation of novel caspase-1 inhibitors through biosynthetic studies of berkeleydione

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