Annual Report 2016

I. Achievement of Research Activities in 2016


M. Tanaka, M. Yoshimura, M. Ogawa, Y. Koyama, T. Shintani, K. Gomi
The C2H2-type transcription factor, FlbC, is involved in the transcriptional regulation of Aspergillus oryzae glucoamylase and protease genes specifically expressed in solid-state culture.
Appl. Microbiol. Biotechnol. ,100:5859–5868 (2016)

N. Li, E. Kunitake, M. Aoyama, M. Ogawa, K. Kanamaru, M. Kimura, Y. Koyama, T. Kobayashi McmA-dependent and -independent regulatory systems governing expression of ClrB-regulated cellulase and hemicellulase genes in Aspergillus nidulans.
Molecular Microbiology, 102: 810–826 (2016)

Y. Shinohara, S. Takahashi, H. Osada, Y. Koyama
Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis.
Scientific Reports, 15th Sep. 2016, doi: 10.1038/srep32865

A. Sato, K. Matsushima, K. Oshima, M. Hattori, Y. KoyamaM
Draft genome sequencing of the highly halotolerant and allopolyploid yeast Zygosaccharomyces rouxii NBRC 1876.
Genome Announc. February 2017 5:e01610-16; doi:10.1128/genomeA.01610-16

I. Nishimura, Y. Shiwa, A. Sato, T. Oguma, H. Yoshikawa, Y. Koyama
Comparative genomics of Tetragenococcus halophilus.
J. Gen. Appl. Microbiol., (In press)

II.Grant project

NISR has started a new project, which supports a research fund in the field of applied biology for the purpose of developing the fermentation and brewing industry.

1) 2016 NISR Research Grant

Masaki Mizunuma (Hiroshima University)
Analysis of the novel stress tolerance mechanism in yeast

Hikaru Seki (Osaka University)
Production of guaianolide sesquiterpene lactones in engineered yeast

Kentaro Takada (The University of Tokyo)
Functions of a novel signal molecule inducing sporulation in Streptomyces species

Kyoko Takahashi (Nihon University)
Regulation of allergic reactions of mast cells by intestinal bacteria and probiotics

Daisuke Umeno (Chiba University)
Evolutionary design of gene expression systems

2) 2016 NISR Young Investigator Research Grant

Takayoshi Awakawa (The University of Tokyo)
Construction of novel meroterpenoid biosynthetic pathway in Aspergillus oryzae

Makoto Hashimoto (Iwate Medical University)
Construction of biosynthetic machinery for polyketides with a bistetrahydrofuran moiety

Yujiro Higuchi(Kyushu University)
Functional analysis of SM proteins for heterologous protein production in Aspergillus oryzae

Takehito Nakazawa (Kyoto University)
Effects of secondary metabolism on sexual development and wood decay in Agaricomycetes

Ryo Nasuno (Nara Institute of Science and Technology)
A novel arginine metabolic pathway regulated by the yeast N-acetyltransferase Mpr1

Yuko Shimamura (University of Shizuoka)
Elucidation of the gene transfer mechanism of staphylococcal enterotoxin A

3) 2015 NISR Research Grant

Wataru Hashimoto(Kyoto University)
Structure-based conversion of the coenzyme specificity in polysaccharide-metabolizing reductases and their applications to biofuel production

Makoto Kimura(Nagoya University)
A basic study toward metabolic engineering of sesquiterpenes

Akira Nakagawa(Ishikawa Prefectural University)
Fermentative production of tetrahydropapaverine and its derivatives using Escherichia coli

Masataka Tsuda(Tohoku University)
Comprehensive analysis of iron-regulated genome expression in environmental bacterium

Takeshi Watanabe(Niigata University)
Mechanism of enzymatic degradation of recalcitrant structural polysaccharide with crystalline structure

4) 2015 NISR Young Investigator Research Grant

Ken-ichi Hashimoto(Tokyo Denki University)
Development of a novel fermentation technology using mechanosensitive channels

Daisuke Hira(Sojo University)
Structure of hydrazine synthase, an electron transfer complex

Hiroto Hirayama(RIKEN)
Functional analysis of a novel endo-O-mannosidase in budding yeast, Saccharomyces cerevisiae

Tomokazu Ito (Nagoya University)
Fermentative production of ophthalmic acid

Chiho Suzuki-Minakuchi(The University of Tokyo)
Degradation pathways of anaerobic benzene-degrading bacteria

5) 2014 NISR Research Grant

Akinori Kato(Kinki University)
Control of bacterial lipopolysaccharide modifications and rare metal nanoparticle production

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