Annual Report 2020

I.Achievement of Research Activities in 2020


M. Ogawa, H. Wada, T. Yoshimura, A. Sato, R. Fukuda, Y. Koyama, and H. Horiuchi
Deletion of Aspergillus nidulans cpsA/rseA induces increased extracellular hydrolase production in solid-state culture partly through the high osmolarity glycerol pathway
J. Biosci. Bioeng., 131, 589-598 (2021)

II.Grant project

NISR has started a new project, which supports a research fund in the field of applied biology for the purpose of developing the fermentation and brewing industry.

1) 2020 NISR Research Grant

Kohsuke HONDA(Osaka University)
Development of a hybrid bio-conversion system consisting of in vivo fermentation and in vitro enzymatic conversion

Yukio KIMATA(Nara Institute of Science and Technology)
Generation of high lipid-producing yeast cells using the endoplasmic reticulum-stress response

Saori KOSONO(The University of Tokyo)
Regulation of a hybrid PDH-ODH complex in Corynebacterium glutamicum

Akira MATSUURA(Chiba University)
Molecular mechanism of the amino acid catabolism induced specifically at the stationary phase of Saccharomyces cerevisiae and its application to cellular longevity

Katsuhide MIYAKE(Meijo University)
Biomass degrading activities of herbivorous land crabs, Chiromantes haematocheir and C. dehaani

Osamu MIZUTANI(University of the Ryukyus)
Elucidation of the mechanism of excessive heat generation in making koji

Motohiro TANI(Kyushu University)
Establishment of a mass production system for ceramide using protection mechanisms against aberrant metabolism sphingolipids

2) 2020 NISR Young Investigator Research Grant

Fumihiro ISHIKAWA(Kindai University)
Enzymatic characterization of NRPS condensation domains using an engineered adenylation domain with an enlarged substrate binding pocket

Atsushi KOUZUMA(Tokyo University of Pharmacy and Life Sciences)
Electrochemical control of bacterial metabolism and its application to bioproduction

Takuto KUMANO(University of Tsukuba)
Elucidation of a thiamin-metabolizing pathway in thiamin-catabolizing microbial consortia

Kazunori KUME(Hiroshima University)
Study of organelle size control in yeast

Tomohiko MATSUZAWA(National Institute of Advanced Industrial Science and Technology (AIST))
Construction of Aspergillus enzyme-library for the production of novel materials

Keisuke WADA(National Institute of Advanced Industrial Science and Technology (AIST))
Construction of aerobic isobutanol-producing strain of Escherichia coli based on enzymatic and metabolic engineering

3) 2019 NISR Research Grant

Hisashi HEMMI(Nagoya University)
Microbial production of isoprenoid using the archaeal mevalonate pathway

Takane KATAYAMA(Kyoto University)
Host-microbe interplay analysis using“apical anaerobic chamber”, a device that enables co-culture of anaerobic gut microbes and host epithelial cells

Takahiro SHINTANI(Tohoku University)
A decrease in secretory protein mRNAs under endoplasmic reticulum stress in filamentous fungi: Elucidation of the mechanism and application in protein secretory production

Hirokazu SUZUKI(Tottori University)
Specific bioproduction using thermophilic cells that produce mesophilic enzymes under temperate conditions

Norio TAKESHITA(University of Tsukuba)
Specificity and diversity of fungal-bacterial interactions

Kenji UEDA(Nihon University)
Unveiling CO2 stimulon underlying the microbial community

4) 2019 NISR Young Investigator Research Grant

Taiki FUTAGAMI(Kagoshima University)
Functional analysis of the putative citrate transporter CitT responsible for the ability to produce citric acid in koji fungi

Development of an interspecies genome recombination method using cell fusion and CRISPR/Cas9 techniques

Shunsuke MASUO(University of Tsukuba)
Novel biosynthesis pathway for aniline derivatives

Atsushi MINAMI(Hokkaido University)
Studies on the biosynthetic enzymes of abscisic acid toward its fermentation production

Takahiro MORI(The University of Tokyo)
Biosynthetic study and production of novel fungal meroterpenoids

Masato TAKAHASHI(University of Tsukuba)
Analysis and application of the influence of accumulating CO2 in the headspace during shake-flask culture on microorganism and microbial community

5) 2018 NISR Young Investigator Research Grant

Kentaro FURUKAWA(Niigata University)
Omics analysis of degradation targets by mitochondrial autophagy

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