Annual Report 2025

Grant project

NISR provides research grants to researchers in the field of applied biology for the purpose of developing the fermentation and brewing industry, and building a sustainable society.


1) 2025 NISR Research Grant

Taku MIZUTANI(The University of Tokyo)
Biosynthetic analysis of microbial metabolites with pharmaceutical useful structures and development of new compound synthesis pathways


Yuichi MOROZUMI(Nara Institute of Science and Technology)
Regulation of cellular heat resistance through respiration in yeast


Wataru NOMURA(Shinshu University)
Investigation of regulatory mechanism of PDC5 expression controlled by fermentation pathway enzyme Pdc1 in yeast


Tomoyuki NUMATA(Kyushu University)
Elucidation of Novel Antiphage Mechanism by CRISPR-Cas System and Development of Antibiotics Using its Biological Functions


Yasushi OGASAWARA(Hokkaido University)
Investigation of novel peptide epimerases and their application to biosynthesize unnatural peptides with D-amino acids


Yasushi TAMURA(Yamagata University)
Unraveling the Molecular Mechanisms Driving Mitochondrial Proliferation


2) 2025 NISR Young Investigator Research Grant

Yuki KANAI(The University of Tokyo)
Solving Genetic and Environmental Conditions for Growth Synchrony Evolution in an Artificial Host-Endosymbiont System


Toma KASHIMA(The University of Tokyo)  
Molecular characterization of the Aspergillus cell wall polysaccharides degradation system from intestinal bacteria


Yuta KUDO(Tohoku University) 
Concise Synthesis and Rapid Identification of Actinomycete Signaling Molecules Aimed at Regulating Secondary Metabolism 


Toshiki NAGAKUBO(University of Tsukuba)  
Elucidation and reprogramming of the mechanism of membrane vesiclesmediated molecule transfer in Corynebacterium glutamicum.


Akihiro NINOMIYA(The University of Tokyo)  
Extensive search for mycoviruses that infect katsuobushi molds


Kosuke SHIRAISHI(Kyoto University)
Development of new regulation technology for gene expression in methylotrophic yeasts through spatiotemporal control of mRNA


3) 2025 NISR Sustainable fields Research Grant

Ryouichi FUKUDA(The University of Tokyo)
Bioconversion of plant-based unused aromatic biomass lignin using yeast


Masayoshi HASHIMOTO(Shizuoka University)

Revealing manipulation mechanism of the plant root-associated microbiome by plants: Toward establishing the microbe-assisted sustainable agriculture


Ryuichi HIROTA(Hiroshima University)
Enhancement of Biological Containment Technology through the Design of Phosphorus Metabolic Pathways


Takehito NAKAZAWA(Kyoto University)
Forward genetics towards selective lignin degradation by the white-rot fungus Pleurotus ostreatus


Atsushi OKAZAWA(Osaka Metropolitan University)
Understanding of the interaction between plants and symbiotic fungi for the activation of soil organic carbon storage


Daisuke SUGIMORI(Fukushima University)
Functional Improvement of Polypropylene-degrading Enzyme


4) 2024 NISR Research Grant

Kenji ARAKAWA(Hiroshima University)
Biosynthetic investigation and structural diversity of azoxyalkene compounds


Kentaro FURUKAWA(Kyushu University)
Elucidation of the mechanism of mitochondrial fission mediated by the coordinated action of Atg44 and Dnm1


Tetsuo KUSHIRO(Meiji University)
Physiological role of novel sterol-amino acid derivatives in fungi


Anna OCHI(Ritsumeikan University)
Elucidation of the mechanism of fermentative production of selenium nanoparticles by microorganisms


Koji OKAMOTO(Osaka University)
Novel mechanisms promoting giant lipid droplet formation in oleaginous yeast


Yoshihiko SAKAGUCHI(Tokushima Bunri University)
Exploring beneficial bioactive substances out of the secreted factors from fecal microbe transplants
〜A therapeutic exploit for intractable diseases utilizing rare useful intestinal inhabitant actinomycetes〜


5) 2024 NISR Young Investigator Research Grant

Yuhei CHADANI(Okayama University)
Expansion of protein synthesis versatility through improvement of translation elongation factors


Nobuyuki OKAHASHI(Osaka University)
Exploring functional lipids in acetic acid bacteria using untargeted lipidomics


Atsushi TAGUCHI(SANKEN Osaka University)
Characterization of membrane transporters in lactic acid bacteria involved in metabolite transport


Ayako YOSHIDA(The University of Tokyo)
Metabolic regulation by a catalytically inactive enzyme homolog


Aya YOSHIMURA(Hokkaido University)
A rational approach to obtaining bacterial secondary metabolites by pseudo-interbacterial communication


6) 2024 NISR Sustainable fields Research Grant

Manabu ARIOKA(The University of Tokyo)
Identification and characterization of factor(s) that enhances the production of plant biomass-degrading enzymes by filamentous fungus and development of methods for its use


Naoya KATAOKA(Yamaguchi University)
Establishment of a novel synthetic biological production system targeting aldehydes based on the utilization of the periplasmic oxidation system of acetic acid bacteria


Junya KATO(National Institute of Advanced Industrial Science and Technology)
Metabolic engineering for commodity chemical production from lignin and CO2 by utilizing H2 as an energy source


Keiichiro KOIWAI(Tokyo University of Marine Science and Technology)
Achieving antibiotic-free shrimp farming using diverse antagonistic bacteria


Rie YATSUNAMI(Institute of Science Tokyo)
The key to oceanic PET plastic issue: Halophilic microorganism and salt tolerant enzyme for a new decomposition approach


7) 2023 NISR Young Investigator Research Grant

Shun SAIO(Keio University)
Analysis of thermotolerance enhancement mechanism of heat shock metabolite (HSM) produced by actinomycete


8) 2023 NISR Sustainable fields Research Grant

Hisashi KAWASAKI(The University of Tokyo)
Development of a method to discover exporters for valuable compounds, and exploration and improvement of exporters


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